I just wanted to chime in and say that both of my 3dconnexion space mice do not work with V5. I added Simplify V5 to the menu in system settings.
MacOS 12.6.1 Monterey
MacBook Pro (15-inch, 2016)
Processor 2.9 Ghz quad-core intel core i7
Memory 16GB
Graphics Radeon Pro 460 4 GB