Currently, if Simplify3D crashes, is terminated, or abnormally exits for other reasons, any settings/profiles/etc changes you've made since the last launch are LOST, which is really quite ridiculous.
Anytime I make a change to any profile and it note "modified"...I save. As I have had larger .stl files crash when trying to scale up to big (upwords of 480mm)...so lessons learned for me @least.