I've had the problem that S3D started very slow (V4.01 and V4.11), sometimes it takes 2 Minutes until the program opens. Today I detected, that the cause of this is the G-Code Library in the Machine Control Panel. There were a lot of items in the list (I'm using S3D since nearly one year). It seems that the program checks all the files for existence and as all my files are on a WIFI-SDCard, it takes some time, especially if the printer is off.
Now what I'm missing is a "Remove ALL Items from Library" Button in the Machine Control Panel, because it's a lot of work to Remove them from the Library Item by Item.
I did a shortcut and cleared the Registry Key 'Communicator/gCodeLibrary'