If some one is interested..
I have made a conf for the spacemouse..
Place the xml into the C:\Program Files\3Dconnexion\3DxWare\3DxWinCore64\Cfg folder.
The spacemouse act as a mouse, so the cursor will move, it's not soo fine, but it work.
I hope the developer of simplify3d will add the offical support for full 3d mouse.