It is just a warning you are exiting "safe zone", safe to ignore it. Safe zone for .6mm nozzle is ~.7mm (0.6*1.2 or 0.6*1.25) width with up to 0.58m (0.6*0.8) layer but s3d adds another relation of layer height < width / 1.2
so with your manual 0.6 width it will allow you to set layer height up to 0.5mm
since your layer is set to 0.45 I assume you are using "combine" either for infill or support, if you have "combine infill every 2 layers" then infill layer will be 0.9mm and that's more than 0.5mm so warning (same for support)
gcodestat integrates with Simplify3D and allow you to
Calculate print time accurately (acceleration, max speed, junction deviation all taken into consideration)
Embed M117 codes into G-Code
Upload your G-Code directly to Octoprint
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For print quality it is recommended to set the Layer Height not in a ratio higher than 1 : 2. Will say the maximum LH is 0.30 mm and below when the extrusion width is set to 0.60 mm. Otherwise you must print near a squared extrusion.