From the "Supported Printers" page after using it to search for your printer:
When you open Simplify3D for the first time, you’ll be prompted to select your printer from a drop-down list. This will automatically apply the optimal settings for your printer and make it easier to create amazing 3D prints.
If you do not find your printer in the drop-down list, please make sure you have updated to the latest version of Simplify3D, or contact us directly so we can assist you with downloading the correct printer profile.
I don't think they could be clearer!