In the software you have "profiles" that you can choose from. Switching between printers is as easy as changing the selection in the combo box. I have created custom profiles (the fff files are simple XML files) for all of my printers, and removed any printers that I do not have (s3d comes with a ton of pre-configured profiles), and now anytime I need to switch to a differnt printer profile, I just select it from the drop down menu.