if you delete WHOLE registry that will kill your settings and everything else
.. not a very good solution
try to delete only GEOMETRY keys
and see if it will fix the problem
these keys only keep "Where did you left your window open last time"
the problem is, windows 10, if you move your s3d window to the non-primary screen (assuming you have multiple monitors) and close it, next time it will try to open on that non-primary screen and it will freeze. it is a wxwidget bug: https://trac.wxwidgets.org/ticket/18532
please try if that works for you... to freeze s3d again move it to non primary screen and exit s3d, next time you start it will try to load on that same screen and it will freeze ... delete the geometry keys and it will work again.
this bug is also reported here: viewtopic.php?p=52776
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