Although I have been using Blender for several years, I only got my first 3D printer last weekend, and after struggling a bit with RepG and noting that the community behind it don't seem to be actively working on new versions, I bought Simplify 3D a couple of days ago to replace RepG.
I was having a seriously confusing time trying to get anything to print successfully and being new, did not know if it was my error (seemed likely), a hardware issue, or my software setup. Each print would start, lay down a partial raft and then the head would stop and deposit a huge blob of goo. It was happening on multiple models.
My set-up: A beefy i7 64bit workstation with 32Gb RAM, Windows 10 (upgraded before I got the printer) and a FlashForge Creator Pro. I was using the configuration assistant to set up for my printer model, and the printer was still at factory presets.
After a bit (actually a lot) of experimentation, I think I have narrowed the issue down to really bad comms over the USB. I am still unable to print anything over the USB link, but transferring the files via SD card works fine. I also noticed in S3D that temperature plots freeze after a period of approx 10 minutes, and updates seen in the "Communication" tab also stop. Each time, the last transaction is a SENT: message from S3D.
Even if the comms are poor, it shouldn't just hang waiting. Are others seeing this issue?