Myself and a few others have experienced the profiles failing to accept changes. This has been happening with users in my Tevo Little Monster group. I noticed it when the head of the printer was dragging along the print when it should have been lifting (retract vert distance) I made a new profile with the same setting as the one I was using and all of a sudden it was lifting the head vert again. I had a few other members having problems with tuning their machine that are using S3D as well. After helping for a while I asked them to do what I had done, and again BAM it was working again. As far as I know these are all Windows PC's. I have old profiles exported, and I was about to delete them but thought they might be useful in some way. I have no way of knowing if the data is any good or not.
Tevo Little MOnster-full Bowden set up
Duet Ethernet running RepRap Firmware
real E3D Titan and Volcano hot end