I haven't previously had cause to print large parts (~500mm on a side), but now that I do I'm finding Simplify3D is having trouble consistently.
After clicking "Prepare to Print" it gets to where it says "Calculating Infill..." and then just hangs. The same behavior happens on several similarly sized parts of varying complexity.
Perhaps there's a way to optimize performance? I don't know. I'm running Debian 9 and one of the parts in question is attached.
I could try this from a beefier computer next week.