Okay...I have some changes for you to try. I'd try them first on a small test piece rather than going for printing with all that PLA.
Extruder tab:
Extrusion multiplier - I think is okay at 0.97
Layer tab:
Reduce Perimeter Outlines to 2. This will give the solid infill the opportunity to fill in some of the smaller sized tops better.
Additions tab:
You could try modding the skirt into a brim by increasing the outlines to 4 and offset to zero. This may then help to stop any edge lifting
Cooling tab:
Change cooling to 100% from layer 1. PLA needs to be cooled asap after extrusion so it hardens and doesn't get pulled by the extruder.
Other tab:
Lower the Solid Infill Underspeed down to no more than 50%. This will stop the raised bits in the infill.
Advanced tab:
Up the overlap percentage for thin wall behaviour to at least 25%
I would look for a good improvement in two ways....no raised bits in the infill when changing direction, and no gaps in the infill on the top surface.
As I've suggested....try this on a smaller test piece first.