I'm currently trying to tune S3D to print a complicated model well. This means I'm constantly opening the software and changing something in the process, then doing another test print.
I've found that if I print the model that loads when I open S3D I get a bad print, holes in one part of the model are filled with infilll.
However, if I remove that model and reload the exact same one, then it prints just fine.
Latest S3d, Windows 7-64 Pro, 8GB RAM, Radeon 7470