By large lines, do you mean long, wide, or tall? With a 0.4mm nozzle you'll need to strike a balance between printing temperature, retraction speed/distance, and printing speed.
Holes in the side of your print can be caused by the opposite effects of what is seen with blobs and zits. Too much retraction/coasting
https://www.simplify3d.com/support/prin ... s-and-zits
Also make sure your filament settings are entered properly, as extrusion amounts are based on the filament diameter measurement.
https://www.simplify3d.com/support/prin ... e-of-print
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