Many of my parts have holes in them for screws, with a hex shaped socket at the end to capture a nut. Many times I'd like the walls of these bolt holes to be 4-5 perimeters thick to give it extra compressive strength in that region. I can change the global perimeter count to 5, but then I end up with 5 perimeters on the entire model, which is massive overkill in virtually all of my models.
In Slic3r you can apparently specify a modifier mesh to make some sections behave differently than others. That's a better solution, but it's still a pain as I have to make a second model just for modifier meshes.
It would be great if we could click surfaces to which we could specify extra perimeters similar to the way supports are specified.
(apologies if this is already a request)