Simplify3D appears to always order each layer as "part", then "support". When fed through Mosaic's Chroma, this generates 2 transitions per layer, and thus consumes a fair amount of material.
Instead, if the ordering was alternated each layer — part → support → layer change → support → part→ layer change — then the material use, and print speed, would be a lot less. This would also work well for 2-to-1 extruders like E3D's Chimera (which I'm about to add to my CR-10v2).
Thank you for your consideration!