Can you post the STL file that you are trying to slice? If you go to the Repair menu and search for non-manifold or self-intersecting surfaces, does it find any errors with the mesh?
I just loaded that printer into v5 and sliced a few files without making any changes and they looked ok.
Maybe try to delete that profile and reload it from scratch to see if it helps.
Otherwise go through settings to see what might be an issue or what might have been changed.