We have also seem a lot of parts where the new V5 slicing behavior works much better than V4. For most of the parts I have helped customers with, the new positive fill mode tends to work better, but alternating fill might work better depending on how you design your parts in CAD. Thankfully, you can pick whichever option works best for you.
If you're interested, there's a longer article about the different options here (the 2nd half of the article has many useful examples):
https://www.simplify3d.com/resources/ar ... sh-errors/