I've used S3D since 2017 and it is the reason 3D printing is still my hobby: it's the only slicer that enabled me to successfully print using my Wanhao i3 Duplicator Plus.
I've moved on from the Wanhao to a pair of Bambu Labs printers (X1C and P1S, also 3 AMS units) and upgraded to S3D 5. I contacted support and got a multimaterial profile (max 4 colors though). After numerous prints with S3D v5 I find it to be underwhelming compared to Orca Slicer and more difficult to work with. For example, the fact that filament profiles are not a separate thing seems crazy now that I've build a library of calibrated filament profiles (Orca Slicer's built-in filament calibration routines are very convenient).
Also underwhelming is the frequency of S3D updates. S3DJason has said, "After the V5 launch we released more updates in that 12 month period than any other year in our past...For the last few months, the team has been focusing on our next major update." People don't want to wait for twice-a-year major updates (5.1.2 was released almost 6 months ago); we want smaller improvements more frequently. I've been testing the new scarf seams feature in Orca Slicer (via nightly builds) and the results are beautiful. It will take a year or more for such an improvement appears in S3D...or it could be in the next release. Who knows? There's no roadmap, no announcements, no transparency. Just this forum...with a sticky "we're hiring" post from 2015.
I think S3D has a lot going for it but the pace of development can't keep up with the open source competition. Slic3r, PrusaSlicer, Bambu Studio, and Orca Slicer have a common codebase so features and fixes flow between them. The 3D printing community contributes to all the projects, and Prusa Research and Bambu Labs both have engineers working on the software.
I would love to see what the community could do with S3D. Personally I think the whole codebase should be made open source while it's still a somewhat relevant slicer because let's face it, S3D falls further behind every day. How crazy is it that you have to contact support if you want multicolor printing? In a commercial software product no less!
The owner of S3D may have a different opinion about releasing the codebase so maybe "open core" is a more palatable option: base features are open source with a commercial premium version. Either way, I'd like to see S3D survive and I don't believe that's possible unless there are drastic changes in the development model.