it's not the machine, problems started for me with 3.1.1 update. I found that it was always crashing on 2 profiles and no other. if I used petg or pla and any profile I setupped for them it would work ok but 2 (out of maybe 7-8) profiles for abs were crashing on almost any change .. changing something in profile or clicking update profile or trying to slice... I deleted those two profiles and 3.1.1 was working without crashes till 4.0 update ... then it started to crash again, I was removing profiles as it was crashing but it didn't help, then I did a virgin installation and it works ok since then (I had maybe total 2 or 3 crashes in some weird situations like my nvidia driver restarted or I loaded some huge part ..)... so now it works properly... win7 64bit on some i7 with 32G ram 1080 nvidia with 3 screens with 2560x1440 and 1 screen 2560x1600 ..
so, I'd say there's def. a bug with profiles upgraded from 3.x, but I can't say that's the only bug... weird beh. was reported with 4k screens, with win10...