I'd be interested in trying out Simplify3D on my Afinia H479 if it could be made to work.. I'm reasonably happy with how their proprietary software slices, but users can't set a nozzle/platform temp other than 210/50 and 270/100!
The only way you could get "any" software to work with the Afinia/Up! ,other than the proprietary software made for it, would require you to strip out the electronic main board and cpu, and install your own. It's has been done by a few people if you go to the pp3dp forums. But I wouldn't recommend it unless your original cpu/main board is dead. For abs prints, I still haven't used any slicer better that Afinia/Up! (Although S3D is faster, it doesn't produce as nice prints) And for PLA it's not bad either