I have just posted a possible issue I found processing http://www.thingiverse.com/thing:44579
Now, I have another little issue with this file: I don't know (but have an idea) what exactly creates the issue, but, with this model it should be easily reproducable.
Try to add manual support to the inside of the "Secret Heart". I know, with bridging this should not really be needed, but, just assume that it is. I cut the model at z=?? and tried to add support. Then Inoticed that the automatic generation of the supports works just as intended, and it's easily possible to remove single piles. But if you try to (re-)add a pile, this won't succeed.
I suppose (but that's just an assumption) that it has something to do with the (invisible) top lid, so the software thought that I wanted to add a support pile on top of this upped lid. If this really is the reason, I think the remedy would be to ignore invisible geometry when doin the heuristics to find where the user wants to place a support pile.
Best regards
Simon