This is your extrusion multiplier on your extruder tab. In S3D it's an actual multiplier of the actual filament amount, e.g., .9 makes 10% less filament come out than 1.0.
If you're printing via USB, there is a flow rate knob on the printer control panel that you can use to adjust the flow rate in real time.
One thing I've done when calibrating is to just make about 5 different cubes on the same print and assign each one it's one process. Then each process just change the multiplier so you end up with .9, .92, .94, .96,.98 or something like that. Then you can see which is best and you don't have to restart the print 5 times.
This is where I think S3D doesn't live up to it's name. Why not just call it "flow rate multiplier". Sure that name is technically not correct, but it would simplify the process tremendously, rather than forcing users to come to the forums for answers.