Examples are attached of the preview of the slicer output for Emmett Lalish's "heart box" at 100% and then again at 50%: While the 100% version is essentially fine, in the scaled down model, many of the polys simply vanish from the slicer output and make it unprintable. I've also included the .STL if you want to troubleshoot it further.
100%:
50%: