I just started using Simplify 3D and my first layers are messy and end up making the bottom of my prints look bad. Below is a picture of two failed prints, you can see the extruder is either putting out too much on the first layer or I have some other setting wrong. If I continue the print it will just clump up and get stuck on the bottom of the final print.
DaVinci 1.0a
Repetier-Firmware-0.92
HatchBox 1.75 Black ABS @ 225C
Bed @ 100C