Whilst sometimes one might set specific part cooling options for targetted layers, I find that 95% of the time I'm instead ramping up my fan to give as much cooling as possible within the constraints of thermal runaway given the material, extrusion rate and heater block.
The settings do vary from print to print and it's very laborious putting in setpoints.
A couple of suggestions:
a) to make it possible to add setpoints by TIME as an alternative to LAYER. Otherwise one has to do a series of mental calculations as to how "quickly in terms of layers" to ramp up given the size of each layer in the particular print job. Don't like doing that!
b) a way to generate a series of setpoints quickly eg a wizard to fill out: "starting at Layer X / Time T ramp up fan by Y % every Z layers / Z minutes"