It would be great if next to USB connections, Simplify3D could also support remote connections to 3D printers.
It's often inconvenient to have a 3D printer connected to your PC or laptop. For one, 3D printers tend to be noisy. And if your computer crashes, your print is ruined. (It's happened to me more often than I'd have liked.) You can put a print-job on an SD card, but then you'd lose remote monitoring and control over your print.
A common solution nowadays is to set up your own 3D printing server with an old laptop or Raspberry Pi, and to start, monitor and control your prints over the local network. That's what I'm doing now. A Raspberry Pi is cheap, and with existing open source software like OctoPrint, it almost works out of the box. My printer is set up in the boiler-room, a small, slightly warm space with no air currents. And the Pi has a camera so I can monitor progress.
OctoPrint has a web-interface, but it's nowhere near as fully featured as Simplify3D. It would be fantastic if Simplify3D could still be used to start, monitor and control prints. I'm sure the OctoPrint REST API could be used to connect the two. And OctoPrint also supports plug-ins, which will allow even greater control.