I've noticed that sometimes, specially for "complicated" structures like:
https://pinshape.com/items/7557-3d-prin ... onoi-style
Simplify3D goes into a "not responding state for up to several hours before eventually doing the job.
I've reproduced the problem both in OSX and Windows.
I have a Macbook pro running el capitan with 8 Gb of ram.
Anybody else having this issue?