I've been very impressed with Simplify3D. It seems to give you control over just about every print setting you could want. However, it would be incredibly useful to me if there was a panel where the extrusion multiplier could be changed by layer, similar to how you can control extruder and bed heater temps and cooling fan speeds. I've found that it's often necessary (with my Ultimaker 2) to increase the extrusion multiplier when sections of a print contain lots of retractions or as the cooling fan kicks into higher speeds.
I understand that I can created multiple processes to accomplish this, but it's tedious to do if you need to change the extrusion multiplier several times during a print, plus you run into problems with adding unnecessary top/bottom solid layers, which can really increase print time and waste filament.
I did a quick search, but didn't find anyone else requesting this feature. I find it hard to believe that nobody else would find it useful...?