Hello,
I just purchased the software and I'm using the default profile for Flashforge creator pro dual extruder. I printed an object using replicatorG about 30 times flawlessly. When I tried to print the same object with S3D the filament sticks to the nozzle creating a larger and larger ball of filament as it goes and totally destroying the print.
I checked the platform and it is leveled. After the failed print I tried again printing with replicatorg and it printed flawless. Again I tried with S3D and same result, filament sticking to nozzle. I'm thinking it has something to do with the way it lays the first layer. It's also a very simple object, just a rectangle with hollowed out letters and it only takes about 10min to print.
I have the same results using slic3r - but I think I did not configure that one properly.