I moved from a Mac to Linux some months ago but hadn't opened Simplify3D yet. I opened Simplify3D (4.1.1) and imported my .fff profile previously exported from the Mac. I then imported a model, edited the process settings accordingly, and tried to slice ("Prepare to Print!"). I got a message in the message area at the bottom of the window: "Failed to create final toolpaths".
I am attaching my .factory file in case it is useful for debugging.