We try to minimize changes to our print profiles for consistency. It would be VERY helpful if there was an option in the system settings that disabled the popup you get when you change from one profile to another in a project, i.e. the dialog that says "Do you want to save the changes you made to 'Profile Name'?".
If you accidentally answer Yes to this (which happens because the No and Yes buttons are reversed from what you normally expect) the profile is permanently changed and that throws everything else off. In general it is better to not have this popup at all and only update the profile by specifically pressing the "Update Profile" button.
I realize that some people may find this popup useful, so that is why I'm suggesting to make it an optional check box in the system settings.